Sickle Cell Disease Essays (513 words) - Hemoglobins,

Sickle Cell Disease The genetic disorder I was told to research was the Sickle Cell Disease. I will explain what mutation causes this disease, the characteristics of it, and what has developed in the area of gene therapy because of it. The Sickle Cell Disease is an inherited disease. The gene for hemogoblin-S (which causes the disease) is the most common inherited blood condition in America; although most people only inherit one copy of the gene for HbS, while the other gene, hemogoblin-A, is normal, and can override HbS, blocking the disease. These people have the HbS trait, but not the disease, therefore leading a normal life. For an offspring to acquire the disease, both parents must have the HbS gene, yet the child only has a 25% chance of having Sickle Cells. You cannot catch the disease, you are born with it and it is present for life. There are many complications and harmful effects as the result of the Sickle Cell Disease. The disease causes hemoglobin in the red blood cells, when it does not receive sufficient oxygen, to form into long, sickle shapes with a sticky, chemical surface. When blood cells are this form, they cannot go through the capillaries, blocking off both blood and oxygen. Fortunately only 20% of all red blood cells become Sickle Cells; the sickle cells have a shorter life span; and most blood cells go through the capillaries before becoming sickle-shaped. The most painful effect known from Sickle Cell Disease are episodes of pain called Sickle Cell Crisis, where the body is in need of oxygen, either from physical activities or a sickle blood cell blocking blood passages that lead to organs. The first day is the worst, where devastating pain goes to the arm, leg, and back, along with the shortness of breath. The other symptoms of Sickle Cells include: strokes, increased infections, early gallstones, yellow discoloring of eyes and skin, low blood cell counts (anemia), and delayed growth. For the cause of the Sickle Cell Disease, there has been many research going on in the area of gene therapy. Labs around the world are trying to fix the basic genetic defect, by placing the correct amino acid in the hemogoblin before or shortly after birth. This method would result in the cure of the root of the problem. Currently researchers are finding a safe way to perform this method. To try to ease the pain caused by Sickle Cell Disease, a substance that can prevent red blood cells from sickling without causing harm to other parts of the body, hydroxyurea was found to reduce the frequency of severe pain, acute chest syndrome and the need for blood transfusions in adult patients with sickle cell disease. Droxia, the prescription form of hydroxyurea, was approved by the FDA in 1998 and is now available for adult patients with sickle cell anemia. Studies will now be conducted to determine the proper dosage for children. The Sickle Cell Disease is a state of suffering, yet it is not as serious as it used to be, where children with the disease was not expected to live through childhood. Now with aggressive treatments, victims' lives are prolongs and improving its quality; and with the researching completed, a full cure of the disease can be possible.

buy custom The Peasant’s War essay

buy custom The Peasant’s War essay Kreis (2002) explains that The Peasants War is one of the popular events that occurred in Europe in the 16th century. The revolt, popularly known as the German Peasants War happened in 1524-1525 consisting of a series of revolts concerning both economy and the religion. Its participation was crosscutting among the nobles, townsfolk s and the peasants. The peak of the conflict was in summer and spring of the year 1525 and concentrated in the now modern Germanys western, southern and central parts. Additionally, revolts were also experienced in neighboring areas of modern Austria, Switzerland and Alsace. Approximately 300, 000, peasants rebels took part and an estimate of 100, 000 died in what was seen today as the greatest and most widespread uprising to ever have been waged against oppression in early Europe before the 1789s French revolution. Komneno article titled The German peasant rebellion of 1525 is a very reliable resource that accounts for the revolt. Other than stating and explaining deeply what the peasants war is, it gives a comprehensive illustration to the reader on what actually happened and the underlying causes and consequences. Another article titled Germany Peasants War, 1524-1525 by Steven Kreis, talks about the same issue, just like its title suggests. Steven explores a brief preistory of the late 15th century and early 16th century and the early medieval state. He then describes the war itself by talking about what prompted the uprising and the consequences it brought along. He enlightens the reader how the war stated due to the local peasants refusal to pay tax and their writing of many articles to express their grievances. Steven also talks about the characteristics of the war and the legacy that was left thereafter. This essay will therefore explore the German peasants war in relation the two articles. They are as earlier introduced, the German peasants rebellion, 1525 by Komneno and Germany Peasants War, 1524-1525 by Steven Kreis. Both the writers have the same opinion on the peasants lives in early Germany. Komneno talks of the peasants as a group that was oppressed. There rights were violated by the landlords and the nobles. This is one of the reasons why the revolt started. I was due the denial of agrarian rights that reforms that were brought along due to Reformation forced the peasants to invoke divine law and demand their rights. On the same issue of oppression among the peasants, Steven observes they were burdened by heavy taxation to cater for the escalating costs of administration for early medieval state. This was due to warfare transition that forced both states and rulers to depend on expensive weaponss and private army instead of knights that were unpaid. Other areas that increased taxation on the peasants were the cannon technology and sons of rulers territories partitioning. They were denied liberty to pick pastors of their choice, the tithe that they were subjected to was also out of proportion and the inclosed common lands were taken away. The judicial system was also unfair and was inclined towards the lordship. Death penalty was also imposed on them among other forms of oppression they underwent, all of them that were listed in a program referred to as Twelve Articles of the Peasantry (Kreis, 2002). Most of the peasants lived in utter illiteracy. Their participation in functions that involved reading and writing was limited. This fact is well demonstrated by Martin Luthers translation of the Bible from German to English in 1522 and 1523. This augmented tension among them. Furthermore both articles talks about poverty that was entrenched in the peasants lives. Peasants were poor especially those who lived in Thuringia, Swabia and Franconia. Their livelihood was mainly depended on fishing and hunting. During the war, they lacked resources as compared to the lords army that they were fighting. They lacked good weapons to fight back and this was one of their major reasons why were defeated. Kreis, (2002) goes ahead to affirm that they weapon they used were often no more than formed hordes and pitchfork. Buy custom The Peasant’s War essay

Business Of The Resale Stores Dissertation Example | Topics and Well Written Essays - 12000 words

Business Of The Resale Stores - Dissertation Example Once this has been done, we will be doing a market segmentation to target our potential customers. Once this has been done, we will design the various strategies required to influence the customers. A detailed plan of how the organization work towards the achievement of its strategic goals and objectives is the operational plan for the business. It provides a clear picture of how the people, teams and the departments of the organizations are collectively working together or the purpose of the business. Finance or the starting capital is the most important thing without which no business can start. Finance is the combination of the acquiring, allocation and the proper management of funds that will actually combine to help in the fulfillment of any business. The financial plan helps the managers to go about with the entire project. It shows the managers and helps them in identifying the different sources of capital and how it can be collected and allocated so that the business may be conducted in a proper fashion. It helps the company to identify the different sources of the capital and how these sources can be properly utilized to actually formulate the business. It also helps in designing and defining the exact way in which the money should be allotted so that the business will be able to breakeven faster and would be successful. In recent times due to the impact of the recession and the inflation on a worldwide basis the consignment shop or resale store is a one-stop solution to all the buyer-seller problems. This is because initially a consignment store or a resale shop is actually a resale business which involves three parties. They are the goods owner or the consignor, the consignee or the seller and the buyer of the resold goods the customer. Goods that are resold or consigned generally are clothes, luxury items, and antiques.

Land law Essay Example | Topics and Well Written Essays - 1500 words - 2

Land law - Essay Example in respect of the land., these can be express covenants agreed between the parties or implied covenants as a matter of law (implied could be the obligation of the tenant to pay rent under the equitable lease. (Shiloh Spinners v Harding)1). Lord Templeman in Street v Mountford2 said that the essential feature of a lease is that exclusive possession of the property is given to a person for specified term, in return of rent. The most important issues in respect of exclusive possession is the fact that it gives ownership to the person for a specified period of time, and because of it being a proprietary interest, it can be assigned, and may be binding on subsequent owners of reversion. In the case of a license it is more of a personal right, binding on parties who created it. (Lloyd v. Dugdale)3. Furthermore, in the case of leases the landlord’s right is restricted to remove tenants and to set rent, this is contrary to what happens in the case of licences. Therefore the distinctio n of lease and licence is of the essence. The deciding factor in respect of lease and licence is that of exclusive possession. Exclusive possession is determined by the facts and surrounding circumstances and other factors. Labels in themselves are therefore not decisive, and so the intention of the parties are not relevant, but the substance of rights that have been created have been construed to be relevant. There are certain exemptions where even if the occupier is in exclusive possession a lease is not created ( Lord Denning in Facchini v Bryson)4. In accordance with Lord Templeman in Street, the fact that the substance of agreement and not the label, is what is important, restricts the situations whereby a license would be construed. From the facts, it can be construed that exclusive possession was granted to Tom. The next element that is important is the fact that it must be for a certain term. This is clearly the case as Lionel agreed to grant Tom a lease for five years. The next element of tenancy is that of rent as specified by Lord Templeman in Street. Clearly Tom was under an obligation pay the rent as well as the premium. Thus in the current situation a lease has been created. As far as creation of a lease is concerned, that is done in two stages, the first being the contract being concluded so as to grant a lease between the landlord and tenant, and the next step is that of the execution of the contract by grant of lease by deed. For the existence of a legal lease of more than three years or where a premium is charged are legal only if they are executed by deed, a requirement under section 52(1) of the Law of Property act 1925. A deed has been defined as a formal written document and in accordance with section 1 of Law of Property (Miscellaneous) Provisions Act 1989, a said document is construed to be a deed only if it expressly declared itself to be a deed and is witnessed by one other person. As far as equitable leases are concerned, they tend t o exist when an enforceable contract is entered into between the landl

Project Evaluation Assignment Example | Topics and Well Written Essays - 1500 words

Project Evaluation - Assignment Example In other words, project evaluation offers a step-by-step procedure of recording, gathering and organizing data and information regarding project outcomes, comprising short-term results of tasks, or project deliverables, and instant and longer-term project results like transformations in behavior, processes or policy outcome from the project (GoogleDocs, 2011; Hughes & Cotterell, 2002; Government of Ontario, 2006). This report discusses some of the important aspects of the project evaluation and its application in technology-intensive enterprises. This report discusses the use and application of the project evaluation processes and various quantitative or qualitative approaches to project evaluation and selection. Usually, project assessment or evaluation is the last stage in the project lifecycle. In this stage analysis is done systematically at the fundamentals of accomplishments as well as failure in the project practice to discover how to plan more effectively for the future. The fundamental aim and objective of this study is to determine the actual value of a program or project as much as probable. In more simple words, project evaluation can be described as "a procedure that tries to find out as methodically as well as objectively as probable the significance, efficiency and influence of actions in the light of the fundamental aims and objectives†. It is, therefore an important examination of the accurate accomplishments and outcomes of a program, project or policy in comparison with the planned tasks, fundamental suppositions, and policy and resource assurance. In addition, it formulates an effort to evaluate impartially the following given main aspects: (Planning Commission, 201 1; Hughes & Cotterell, 2002; Government of Ontario, 2006) The significance and strength of the project aims and objectives and design of the project/program in scenario of wider problems of project development policy, project priorities as well as strategies with

Academic Performance And Motivation Education Essay

Academic Performance And Motivation Education Essay This chapter aims to answer the following question, what are the differences in motivation between male and female, differences in motivation among the 3 year of study, and relationship between motivation and academic performance among UTAR students. This studys results suggest there is statistically significant difference in academic motivation between male and female, and significant difference in motivation among 3 years of study among UTAR students. However, there is significant relationship between motivation and academic performance among UTAR students. In addition, each variable will be examined for significant and non-significant differences between the genders, as well as applicability to previous studies, significance to college enrollment and possible future research. Motivation Results for motivation suggested there are statistically differences between male and female. This might be interpreted as meaning the more motivated a student is, the more likely they are to enroll in, attend regularly and graduate from University or College. Academic Motivation Scale-College Version (AMS-C) was used to measure motivation, which reported average scores of à ¢Ã¢â€š ¬Ã‚ ¦.. for male students andà ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦for female students (see Tableà ¢Ã¢â€š ¬Ã‚ ¦ in Chapter 4). The data represents a difference found between the two groups, with the female students reporting higher levels of intrinsic motivation. When comparing male students and female students, results of this study suggest there are higher levels of motivation reported by the femala students. The current study found similarities to past research. According to Nadia (2010) indicated that female students more likely to have academic ethics than male students, which are characterized by higher academic attainment. Furthermore, the findings of the study show that female students were intrinsically motivated than males. In contrast, male students were extrinsically motivated than females. The possible explanations of these findings are that males are expected to be the main breadwinner of the family in society (Nadia, 2010). Whereas, for females, they are academic performance and motivation is based on self-exploration and internal satisfaction (Nadia, 2010). Data have shown that there is a significant link between a parents education and a childs motivation for college enrollment. Other research suggests, for first-generation students, the motivation to enroll in college is a deliberate attempt to improve his or her social, economic, and occupational standing (Ayala Striplen, 2002). Academic Performance and Motivation On top of that, findings suggest that there is significant relationship (r=.;n-)between motivation and academic performance among UTAR students. Academic performance was using grade point average (GPA) and the average of (B-). These findings are consistent with previous literature. Johnson (1996) and other researchers also found out that academic achievement is highly correlated with students motivation (as cited in Nadia, 2010). Due to the previous research, the types of the motivation can affect on the performance of the students. This is because intrinsic and extrinsic motivation effects on the achievement and goals of the students performance. Students enjoyment when they learn new things is an example of intrinsic motivation. For instance, student may do their homework because they find it interesting and satisfying to learn about certain subjects (Isiksal, 2010). Findings also supported previous research based on SDT, which posit the relation between students being intrinsically motivated and academically successful (Turner, Chandler Heffer, 2009). As Fortes, Rodrigues and Tchantchane (2010) pointed out that when students are realize that the academic courses can improve their career prospects, they will be motivated to improve their academic performance as well. These types of students are tending to more on extrinsic motivation and other such as they want to get more reward or praise. Moreover, students with ammotivation also can affect their academic performance. They will experience feelings of incompetence and expectancies of uncontrollability they perceive their behavior as caused by forces out their own control. They feel undeceived and start asking themselves why in the world, why they go to school or they may stop participating in academic activities (Nadia, 2010). Year of Study The results for motivation among 3 years of study in UTAR students. This could be due to the differences in age and experience during their study in University. A research done by Uguroglu (1982) and McClure (1986) found that older students were more stable in certain personality characteristics and have higher achievement motivation and self-control than the younger one (as cited in Habibah Elias Rafaei abdul Rahman, 1995). Female stuents hv in general a better motivation profile and spent more time studying for their courses. Due to these observations, it is expected that the average female student would be the significant better performer in her first year at university. But it was observed, that the group of female students did not scored better in their first year. Students find increasingly little that is directly relevant or useful in their daily lives or those students ability belief and goal orientations shift from being positive and task focused to being more pessimistic and performance focused in their study. Intrinsic motivation is certainly not being supplanted by extrinsic motivation in the second year in University (Lepper, Iyengar Corpus, 2005) . Limitations of the Study There have several limitations that are identified during the progress of completing in this study such as that is related to population sample limitations to only one University, with a limited amount of student willing or able to participate. It might be more beneficial towards this type of research to have a wider range of University involvement in hopes to have a larger amount of student participants. With a larger amount of participants, this research could possible give results that are more inferential and accurate from the data. In addition, there is the lack of a large sample size within the target population. Instead of focusing research efforts on just one University, students from all Kampar,Perak state University or College could be considered as potential participants. It suggested that a larger population yield a larger amount of participants and could potentially lower instances of extraneous flaws thus results are reliable and valid to all state-level University or College populations. On top of that, this research is only focusing on the demographic variable, such as years of study, gender and GPA. However, there were other variables that might affect the level of motivation and academic performance. For example, classrooms environment, parental-child attachment styles, parental behavior, urban or rural area, peer pressure, courses, faculty, socioeconomic status (SES) and others. Those variables may account for the shift in intrinsic and extrinsic motivation. Another possible flaw is an inadequate time to collect the questionnaires. Even have give enough time for participants to fill in the questionnaire, but they may not collaboration to participate answering the questionnaire. Additional research is needed in order to get the reliability results and to determine the generalization of such findings to other populations and cultures. Recommendations for Future Research With the conclusion of this study, some possible recommendations for future research haven arisen. In the future, studies could aim to focus on younger demographic where intervention can be assesses and applied. This would include factors that are currently lacking, like motivation and college academic preparation. This research study discovery that preparing people for college starts at young age, as early as elementary school. This information could initiate further research, which aspires at a much younger demographic than the current study. Possible development of interventions for implementing programs that targets for the purpose of college preparation and provide the social support needed for these youth to be motivated to want and attend college could also be explored. Moreover, it is important assess the absence of parental figures, like with those in prison or who have passed away. For example, if a child is raised by a single parent, it might be important to narrow down factors and see how perceived social support and motivation apply to his or her circumstance. Once again by knowing what could contribute to these individuals can further assist those interested in implementing programs that target these particular populations. In the Western countries, researchers are very focusing about youngers education and performance in school, and there have many research talking about this, but yet very few research in Malaysia. Therefore more research should be conducted in order to know more about the students motivation in school, how this can effect on their learning and the perception or early support services for parents. Therefore, future research could be important in finding which variables are contributing to or the level of motivation in homes as children develop ideals for future. This would be helped to improve the education and getting more researches in Malaysia. Conclusion

Converting Your Manual Bookkeeping Essay

If you’re converting a manual bookkeeping system to a computerized system, your conversion will take a bit more time than just starting fresh because you need to be sure your new system starts with information that matches your current books. The process for entering your initial data varies depending on the software you’ve chosen. To ensure that you properly convert your bookkeeping system, use the information that comes with your software; read through the manual, review the startup suggestions made as you set up the system, and pick the methods that best match your style of operating. The best time to convert is at the end of an accounting period. That way, you won’t have to do a lot of extra work adding transactions that already occurred during a period. For example, if you decide to computerize your accounting system on March 15, you’d have to add all the transactions that occurred between March 1 and March 15 into your new system. It’s just easier to wait until April 1 to get started even if you buy the software on March 15. While you can convert to a computerized accounting system at the end of a month, your best time to do it is at the end of a calendar or fiscal year. Otherwise, you have to input data for all the months of the year that have passed. Whenever you decide to start your computerized bookkeeping, use the data from your trial balance that you used to close the books at the end of most recent accounting period. In the computerized system, enter the balances for each of the accounts in your trial balance. Asset, liability, and equity accounts should have carry-over balances, but Income and Expense accounts should have zero balances. Of course, if you’re starting a new business, you won’t have a previous trial balance. Then you just enter any balances you might have in your cash accounts, any assets your business may own as it starts up, and any liabilities that your business may already owe relating to startup expenses. You also add any contributions from owners that were made to get the business started in the Equity accounts. After you enter all the appropriate data, run a series of financial reports, such as an income statement and balance sheet, to be sure the data is entered and formatted the way you like it. It’s a lot easier to change formatting when the system isn’t chock-full of data. You need to be sure that you’ve entered the right numbers, so verify that the new accounting system’s financial reports match what you created manually. If the numbers are different, now’s the time to figure out why. Otherwise the reports you do at the end of the accounting period will be wrong. If the numbers don’t match, don’t assume the only place an error could be is in the data entered. You may find that the error is in the reports you developed manually. Of course, check your entries first, but if the income statement and balance sheet still don’t look right, double-check your trial balances as well. Read more: http://www. dummies. com/how-to/content/converting-your-manual-bookkeeping-to-a-computeriz. html#ixzz1SMwAbn8q